5,054 research outputs found
Why HIV Positive Patients on Antiretroviral Treatment and/or Cotrimoxazole Prophylaxis Use Traditional Medicine: Perceptions of Health Workers, Traditional Healers and Patients: A Study in Two Provinces of South Africa
The study explored the perceptions, knowledge and attitudes of patients, health workers and traditional healers about the use of traditional medicine and Anti Retroviral Therapy (ART). The study explored the perceptions, knowledge and attitudes of patients, health workers and traditional healers about the use of traditional medicine and Anti Retroviral Therapy (ART), using an exploratory qualitative design in two provinces of South Africa: an urban township health facility in the Western Cape, and a rural district hospital in KwaZulu-Natal (KZN) with antennal HIV rate of 32% and 28%’respectively. In-depth interviews were conducted with 14 participants: six HIV patients on ART and using Traditional Medicine(TM), two doctors, two nurses and four traditional healers. Two focus group discussions - one at each site - were held with community health workers who work with HIV-positive patients (Western Cape [5] and in KZN [4]). Patient said to have used Traditional Healing Practices (THP) before they were diagnosed with HIV, and some who have been diagnosed with HIV continue using TM in conjunction with ART and/or Cotrimoxazole prophylaxis. Patients preferred not to disclose THP to health professionals because of lack of support and understanding. Patients utilize THP because of family expectations, privacy and confidentiality, especially when they have not disclosed their HIV status. Healthcare professionals had strong negative opinions about THP, especially for HIV-positive patients. Traditional healers supported the patient’s rationale for THP use. This study revealed a need to better understand factors involved in patients’ choosing to use THP concurrently with ART
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Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials.
Rifapentine is a highly active antituberculosis antibiotic with treatment-shortening potential; however, exposure-response relations and the dose needed for maximal bactericidal activity have not been established. We used pharmacokinetic/pharmacodynamic data from 657 adults with pulmonary tuberculosis participating in treatment trials to compare rifapentine (n = 405) with rifampin (n = 252) as part of intensive-phase therapy. Population pharmacokinetic/pharmacodynamic analyses were performed with nonlinear mixed-effects modeling. Time to stable culture conversion of sputum to negative was determined in cultures obtained over 4 months of therapy. Rifapentine exposures were lower in participants who were coinfected with human immunodeficiency virus, black, male, or fasting when taking drug. Rifapentine exposure, large lung cavity size, and geographic region were independently associated with time to culture conversion in liquid media. Maximal treatment efficacy is likely achieved with rifapentine at 1,200 mg daily. Patients with large lung cavities appear less responsive to treatment, even at high rifapentine doses
Perceptual Context in Cognitive Hierarchies
Cognition does not only depend on bottom-up sensor feature abstraction, but
also relies on contextual information being passed top-down. Context is higher
level information that helps to predict belief states at lower levels. The main
contribution of this paper is to provide a formalisation of perceptual context
and its integration into a new process model for cognitive hierarchies. Several
simple instantiations of a cognitive hierarchy are used to illustrate the role
of context. Notably, we demonstrate the use context in a novel approach to
visually track the pose of rigid objects with just a 2D camera
The removal of thermally aged films of triacylglycerides by surfactant solutions
Thermal ageing of triacylglycerides (TAG) at high temperatures produces films which resist removal using aqueous surfactant solutions. We used a mass loss method to investigate the removal of thermally aged TAG films from hard surfaces using aqueous solutions of surfactants of different charge types. It was found that cationic surfactants are most effective at high pH, whereas anionics are most effective at low pH and a non-ionic surfactant is most effective at intermediate pH. We showed that the TAG film removal process occurs in several stages. In the first ‘‘lag phase’’ no TAG removal occurs; the surfactant first partitions into the thermally aged film. In the second stage, the TAG film containing surfactant was removed by solubilisation into micelles in the aqueous solution. The effects of pH and surfactant charge on the TAG removal process correlate with the effects of these variables on the extent of surfactant partitioning to the TAG film and on the maximum extent of TAG solubilisation within the micelles. Additionally, we showed how the TAG removal is enhanced by the addition of amphiphilic additives such as alcohols which act as co-surfactants. The study demonstrates that aqueous surfactant solutions provide a viable and more benign alternative to current methods for the removal of thermally aged TAG films
The Seasonal Natural History of the Ant, Dolichoderus mariae, in Northern Florida
Dolichoderus mariae Forel, (Hymenoptera: Formicidae) is an uncommon, monomorphic but locally abundant, reddish-brown ant of peculiar nesting habits, whose range includes most of the eastern USA. In north Florida the ant excavates soil under wiregrass clumps or other plants with fibrous roots to form a single, large, shallow, conical or ovoid chamber broadly open to the surface around the plant base. Colonies are highly polygyne and, during the warm season, inhabit multiple nests connected only by above ground trails, over which nests exchange workers. Although monomorphic, worker size may differ significantly between colonies. The colony cycle is dominated by strong seasonal polydomy. From one or two over-wintering nests, the colonies expanded to occupy up to 60 nests by late summer, then retract once more to one or two nests by mid-winter. The worker-to-queen ratio changed greatly during this cycle, with over two thousand workers per queen during fall and winter, dropping to a low of about 300 during midsummer. Most of these summer queens probably die during the fall. Colonies reoccupy roughly the same area year to year even though they contract down to one or two nests in winter. Observation of fights in the contact zone between colonies suggested that the colonies are territorial. The ants subsist by tending aphids and scale insects for honeydew and scavenging for dead insects within their territories
Multidimensional ground reaction forces and moments from wearable sensor accelerations via deep learning
Objective: Monitoring athlete internal workload exposure, including prevention of catastrophic non-contact knee injuries, relies on the existence of a custom early-warning detection system. This system must be able to estimate accurate, reliable, and valid musculoskeletal joint loads, for sporting maneuvers in near real-time and during match play. However, current methods are constrained to laboratory instrumentation, are labor and cost intensive, and require highly trained specialist knowledge, thereby limiting their ecological validity and volume deployment. Methods: Here we show that kinematic data obtained from wearable sensor accelerometers, in lieu of embedded force platforms, can leverage recent supervised learning techniques to predict in-game near real-time multidimensional ground reaction forces and moments (GRF/M). Competing convolutional neural network (CNN) deep learning models were trained using laboratory-derived stance phase GRF/M data and simulated sensor accelerations for running and sidestepping maneuvers derived from nearly half a million legacy motion trials. Then, predictions were made from each model driven by five sensor accelerations recorded during independent inter-laboratory data capture sessions. Results: Despite adversarial conditions, the proposed deep learning workbench achieved correlations to ground truth, by GRF component, of vertical 0.9663, anterior 0.9579 (both running), and lateral 0.8737 (sidestepping). Conclusion: The lessons learned from this study will facilitate the use of wearable sensors in conjunction with deep learning to accurately estimate near real-time on-field GRF/M. Significance: Coaching, medical, and allied health staff can use this technology to monitor a range of joint loading indicators during game play, with the ultimate aim to minimize the occurrence of non-contact injuries in elite and community-level sports
Ballistic nanofriction
Sliding parts in nanosystems such as Nano ElectroMechanical Systems (NEMS)
and nanomotors, increasingly involve large speeds, and rotations as well as
translations of the moving surfaces; yet, the physics of high speed nanoscale
friction is so far unexplored. Here, by simulating the motion of drifting and
of kicked Au clusters on graphite - a workhorse system of experimental
relevance -- we demonstrate and characterize a novel "ballistic" friction
regime at high speed, separate from drift at low speed. The temperature
dependence of the cluster slip distance and time, measuring friction, is
opposite in these two regimes, consistent with theory. Crucial to both regimes
is the interplay of rotations and translations, shown to be correlated in slow
drift but anticorrelated in fast sliding. Despite these differences, we find
the velocity dependence of ballistic friction to be, like drift, viscous
Ultrafast changes in lattice symmetry probed by coherent phonons
The electronic and structural properties of a material are strongly
determined by its symmetry. Changing the symmetry via a photoinduced phase
transition offers new ways to manipulate material properties on ultrafast
timescales. However, in order to identify when and how fast these phase
transitions occur, methods that can probe the symmetry change in the time
domain are required. We show that a time-dependent change in the coherent
phonon spectrum can probe a change in symmetry of the lattice potential, thus
providing an all-optical probe of structural transitions. We examine the
photoinduced structural phase transition in VO2 and show that, above the phase
transition threshold, photoexcitation completely changes the lattice potential
on an ultrafast timescale. The loss of the equilibrium-phase phonon modes
occurs promptly, indicating a non-thermal pathway for the photoinduced phase
transition, where a strong perturbation to the lattice potential changes its
symmetry before ionic rearrangement has occurred.Comment: 14 pages 4 figure
Characterization of 18 polymorphic microsatellite loci for the western rock lobster Panulirus cygnus
Coulomb Interactions between Cytoplasmic Electric Fields and Phosphorylated Messenger Proteins Optimize Information Flow in Cells
Normal cell function requires timely and accurate transmission of information from receptors on the cell membrane (CM) to the nucleus. Movement of messenger proteins in the cytoplasm is thought to be dependent on random walk. However, Brownian motion will disperse messenger proteins throughout the cytosol resulting in slow and highly variable transit times. We propose that a critical component of information transfer is an intracellular electric field generated by distribution of charge on the nuclear membrane (NM). While the latter has been demonstrated experimentally for decades, the role of the consequent electric field has been assumed to be minimal due to a Debye length of about 1 nanometer that results from screening by intracellular Cl- and K+. We propose inclusion of these inorganic ions in the Debye-Huckel equation is incorrect because nuclear pores allow transit through the membrane at a rate far faster than the time to thermodynamic equilibrium. In our model, only the charged, mobile messenger proteins contribute to the Debye length.Using this revised model and published data, we estimate the NM possesses a Debye-Huckel length of a few microns and find this is consistent with recent measurement using intracellular nano-voltmeters. We demonstrate the field will accelerate isolated messenger proteins toward the nucleus through Coulomb interactions with negative charges added by phosphorylation. We calculate transit times as short as 0.01 sec. When large numbers of phosphorylated messenger proteins are generated by increasing concentrations of extracellular ligands, we demonstrate they generate a self-screening environment that regionally attenuates the cytoplasmic field, slowing movement but permitting greater cross talk among pathways. Preliminary experimental results with phosphorylated RAF are consistent with model predictions.This work demonstrates that previously unrecognized Coulomb interactions between phosphorylated messenger proteins and intracellular electric fields will optimize information transfer from the CM to the NM in cells
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